Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SERPINB3 |
| Gene Name: | SERPINB3 |
| Protein Full Name: | Serpin B3 |
| Alias: | SCC; SCCA; SCCA1; SCCA-1; SCCA-PD; SPB3; Squamous cell carcinoma antigen 1; T4-A |
| Mass (Da): | 44565 |
| Number AA: | 390 |
| UniProt ID: | P29508 |
| Locus ID: | 6317 |
| COSMIC ID: | SERPINB3 |
| Gene location on chromosome: | 18q21.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.89 |
| Normal role description: | SERPINB3 is a serine and cysteine protease inhibitor. It has been found to regulate apoptosis and immune response. Cancer cells expressing SERPINB3 were found to be resistant to apoptosis induced by anti-cancer drugs and TNFa induced apoptosis. It was also found associated with changes in cell morphology and cell migration in cancer cells. |