Cancer Protein Description

This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Protein Name: RBMS1
Gene Name: RBMS1
Protein Full Name: RNA-binding motif, single-stranded-interacting pro
Alias: C2orf12; C-myc gene single strand binding 2; C-Myc gene single strand binding 2; C-myc gene single strand binding protein 2; DKFZp564H0764; HCC-4; MSSP; MSSP1; MSSP-1; MSSP-2; MSSP-3; RNA binding motif, single stranded interacting 1; RNA binding motif, single stranded interacting protein 1; SCR2; Single-stranded DNA-binding MSSP-1; Suppressor of cdc 2 (cdc13) with RNA binding motif 2; Suppressor of CDC2 with RNA- binding motif 2; YC1
Mass (Da): 44505
Number AA: 406
UniProt ID: P29558
Locus ID: 5937
COSMIC ID: RBMS1
Gene location on chromosome: 2q24.2
Number of cancer specimens: 19557
Percent of cancer specimens with mutations: 0.26
Commentary on involvement of protein in cancer: Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.


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