Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PPP2R1A |
| Gene Name: | PPP2R1A |
| Protein Full Name: | Serine/threonine-protein phosphatase 2A 65 kDa reg |
| Alias: | 2AAA; Medium tumor antigen-associated 61 kDa protein; PP2A, A, PR65-alpha isoform; PP2A, A, R1-alpha isoform; PP2A, subunit A, PR65-alpha isoform; PR65A; Protein phosphatase 2 (formerly 2A) regulatory subunit A, alpha isoform |
| Mass (Da): | 65309 |
| Number AA: | 589 |
| UniProt ID: | P30153 |
| Locus ID: | 5518 |
| COSMIC ID: | PPP2R1A |
| Gene location on chromosome: | 19q13.41 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 22037 |
| Percent of cancer specimens with mutations: | 1.24 |
| General distribution of mutations: | Narrow |
| Location of most mutations: | Two main clusters at AA 179-183 and AA 249-260, with only 1 insertion and 1 deletion and no complex mutations. |
| Commonly recorded point mutations: | R183W (29); P179R (28); |
| Normal role description: | PPP2R1A is a protein-serine/threonine phosphatase regulatory protein |
| Commentary on involvement of protein in cancer: | R183 is located in the HEAT 5 domain and S256 in the HEAT 7 domain. Both are encompassed within the PP2A subunit B binding region. |