Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Cdc27 |
| Gene Name: | CDC27 |
| Protein Full Name: | Cell division cycle protein 27 homolog |
| Alias: | CDC27Hs; H-NUC |
| Mass (Da): | 91867 |
| Number AA: | 824 |
| UniProt ID: | P30260 |
| Locus ID: | 996 |
| COSMIC ID: | CDC27 |
| Gene location on chromosome: | 17q21.32 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19872 |
| Percent of cancer specimens with mutations: | 0.86 |
| Normal role description: | CDC27 is a component of anaphase promoting complex/cyclosme and has roles in mediating cell cycle progression. It regulates the degredation of target proteins such as B-type cyclins. It has also been shown to interacted with mitotic checkpoint proteins. Mitotic timing and progression may be a key role of this protein. |