Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Cdc25B |
| Gene Name: | CDC25B |
| Protein Full Name: | M-phase inducer phosphatase 2 |
| Alias: | CDC25HU2; CDC25M2; Cell division cycle 25 B; EC 3.1.3.48; M-phase inducer phosphatase 2; MPIP2 |
| Mass (Da): | 64987 |
| Number AA: | 580 |
| UniProt ID: | P30305 |
| Locus ID: | 994 |
| COSMIC ID: | CDC25B |
| Gene location on chromosome: | 20p13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20338 |
| Percent of cancer specimens with mutations: | 0.4 |
| Normal role description: | CDC25B is a protein-dual specificity phosphatase. Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. As this gene is a inducer of mitotic progression, mutations leading to its increased activity could classify it as an oncoprotein. |
| Commentary on involvement of protein in cancer: | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. |