Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Cdc25C |
| Gene Name: | CDC25C |
| Protein Full Name: | M-phase inducer phosphatase 3 |
| Alias: | CDC25; CDC25M1; Cell division cycle 25 C; EC 3.1.3.48; M-phase inducer phosphatase 3; MPI1B; MPIP3 |
| Mass (Da): | 53365 |
| Number AA: | 473 |
| UniProt ID: | P30307 |
| Locus ID: | 995 |
| COSMIC ID: | CDC25C |
| Gene location on chromosome: | 5q31.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20337 |
| Percent of cancer specimens with mutations: | 0.37 |
| Normal role description: | CDC25C is a protein-dual specificity phosphatase. It is required for progression of cell cycle through G2 phase. Experiments with mutant CDC25C proteins create cells in G2 arrest. Therefore it appears that mutations causing loss of function would inhibit cancer progression but this has yet to be established |