Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NKTR |
| Gene Name: | NKTR |
| Protein Full Name: | NK-tumor recognition protein |
| Alias: | Natural killer triggering receptor; Natural killer-tumor recognition sequence; Natural-killer cells cyclophilin-related protein; NK-TR protein; P104 |
| Mass (Da): | 165677 |
| Number AA: | 1462 |
| UniProt ID: | P30414 |
| Locus ID: | 4820 |
| COSMIC ID: | NKTR |
| Gene location on chromosome: | 3p22.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.89 |
| Normal role description: | NKTR is a membrane-anchored protein present on the surface of natural killer cells and functions to facilitate the binding to their targets. It is also involved in protein folding and is very important for the killing of tumour cells by NK cells. Its expression is regulated by IL-2 activation of the NK cell. |
| Commentary on involvement of protein in cancer: | Only 2 ovarian- and mouth cancer samples, and 1 skin cancer sample included in Sanger COSMIC |