Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Axl |
| Gene Name: | AXL |
| Protein Full Name: | Tyrosine-protein kinase receptor UFO |
| Alias: | Adhesion-related kinase; ARK; AXL oncogene; AXL receptor tyrosine kinase; EC 2.7.10.1; JTK11; Kinase AXL; UFO |
| Mass (Da): | 97437 |
| Number AA: | 894 |
| UniProt ID: | P30530; Q15839 |
| Locus ID: | 558 |
| COSMIC ID: | AXL |
| Gene location on chromosome: | 19q13.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20601 |
| Percent of cancer specimens with mutations: | 1.03 |
| Normal role description: | AXL is a receptor-tyrosine kinase that is activated upon binding the growth factor GAS6. Some of its signal pathways include PI3K/AKT, RAS and ERK. It regulates cell survival and proliferation, preventing apoptosis, migration, cell adhesion, cell aggregation and homophillic binding. In cancer, it is found to be overexpressed and contribute to metastasis and invasion. Upregulation of this gene is observed in numerous cancers; in most cases expression negatively correlates with prognosis. |