Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CORO1A |
| Gene Name: | CORO1A |
| Protein Full Name: | Coronin-1A |
| Alias: | CLABP; Clabp TACO; CLIPINA; COR1A; CORO1; CORO1A; Coronin, actin binding protein, 1A; Coronin, actin-binding protein, 1A; Coronin, actin-binding, 1A; Coronin-1; Coronin-like protein A; Coronin-like protein p57; FLJ41407; HCORO1; P57; TACO; Tryptophan aspartate-containing coat protein |
| Mass (Da): | 51026 |
| Number AA: | 461 |
| UniProt ID: | P31146 |
| Locus ID: | 11151 |
| COSMIC ID: | CORO1A |
| Gene location on chromosome: | 16p11.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.39 |
| Normal role description: | This gene encodes a member of the WD repeat protein family. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. CORO1A may be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, CORO1A retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. Role in oncogenesis not well described. |