Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | S100A7 |
| Gene Name: | S100A7 |
| Protein Full Name: | Protein S100-A7 |
| Alias: | S100 calcium-binding protein A7 |
| Mass (Da): | 11471 |
| Number AA: | 101 |
| UniProt ID: | P31151 |
| Locus ID: | 6278 |
| COSMIC ID: | S100A7 |
| Gene location on chromosome: | 1q21.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.17 |
| Normal role description: | Calcium-binding protein - cytoplamsic and secreted. Protein binding; RAGE receptor binding; zinc ion binding; calcium ion binding; keratinocyte differentiation; sequestering of metal ion; response to reactive oxygen species; epidermis development; innate immune response; response to lipopolysaccharide; angiogenesis; defense response to Gram-negative bacterium. Upregulation has been observed in bladder, breast, head and neck, lung, mouth, ovarian, skin, and stomach tumors. |