Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HOXA9 |
| Gene Name: | HOXA9 |
| Protein Full Name: | Homeobox protein Hox-A9 |
| Alias: | Homeobox A9; HOX1; HOX1G; Hox-1G |
| Mass (Da): | 30172 |
| Number AA: | 272 |
| UniProt ID: | P31269 |
| Locus ID: | 3205 |
| COSMIC ID: | HOXA9 |
| Gene location on chromosome: | 7p15 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.2 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | Translocation t(7;11)(p15;p15) with NUP98 in acute myeloid leukemia; Translocation t(7;17)(p15;q23) with MSI2 in chronic myeloid leukemia |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | HOXA9 is a sequence-specific transcription factor which plays a role in regulating development and provides cells with positional identities along the anterior-posterior axis. It can be regulated by PKC phosphorylation and evidence suggests that PKC regulates HOXA9 in myeloid cell proliferation and differentiation. Ectopic expression of HOXA9 in ovarian surface epithelial cells gave rise to papillary tumors. |