Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HOXA11 |
| Gene Name: | HOXA11 |
| Protein Full Name: | Homeobox protein Hox-A11 |
| Alias: | Homeobox protein Hox-1I |
| Mass (Da): | 34486 |
| Number AA: | 313 |
| UniProt ID: | P31270 |
| Locus ID: | 3207 |
| COSMIC ID: | HOXA11 |
| Gene location on chromosome: | 7p15-7p14.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.27 |
| Deregulated in translocations: | t(7;7)(p15;q34) places 5'HOXA cluster genes (7p15) under the influence of strong enhancers within the TCRBlocus (7q34) resulting in ectopic expression of especially HOXA10 and HOXA11; this does not result in a fusion protein, but ectopic expression of HOX |
| Normal role description: | HOXA11 is a transription factor that has temporal-spatial regulation during embryonic development. Translocations in this gene resulting in its upregulation have been implicated in T-cell acute lymphoblastic leukemia. |