Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CCR1 |
| Gene Name: | CCR1 |
| Protein Full Name: | C-C chemokine receptor type 1 |
| Alias: | C-C CKR-1; CC-CKR-1; CCR-1; Chemokine (C-C motif) receptor 1; CKR-1; CMKBR1; CMKR1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; MIP1aR; RANTES receptor; RANTES-R; SCYAR1 |
| Mass (Da): | 41173 |
| Number AA: | 355 |
| UniProt ID: | P32246 |
| Locus ID: | 1230 |
| COSMIC ID: | CCR1 |
| Gene location on chromosome: | 3p21.31 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20149 |
| Percent of cancer specimens with mutations: | 0.38 |
| Deregulated in translocations: | Multiple Myelomas (5%-10%), fusion partner is c-maf. |
| Normal role description: | CCR1 is a G protein-coupled chemokine receptor which interacts with C-C type chemokines (CCL). CCR1 is predominantly expressed on the surface of leukocytes and functions in recruitment of effector immune cells to sites of inflammation. CCR1 also appears to play a role in the maintenance of stem cell proliferation. The overexpression of CCR1 has been observed in a multitude of cancers including; hematolymphoid neoplasia, hepatocellular carcinomas, colorectal cancers, lung cancer, oral squamous cell carcinoma, ovarian cancer, prostate cancer, breast cancer, glioma and osteogenic sarcomas. However, CCR1 appears to have a tumour suppressive role in multiple myeloma as decreased expression of the receptor was observed in active cancer tissues. |