Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CDA |
| Gene Name: | CDA |
| Protein Full Name: | Cytidine deaminase |
| Alias: | Cytidine aminohydrolase |
| Mass (Da): | 16167 |
| Number AA: | 146 |
| UniProt ID: | P32320 |
| Locus ID: | 978 |
| COSMIC ID: | CDA |
| Gene location on chromosome: | 1p36.12 |
| Cancer protein type: | OP by chemotherapy resistance |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES by inactivation of chemotherapeutic |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.18 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | CDA is an enzyme that utilizes exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. It deaminates cytidine or deoxycytidine to uridine and deoxyuridine respectively via a hydrolysis reaction. It can also inactivate cytosine arabinoside, a chemotherapeutic nucleoside analog for the treatment of certain childhood leukmias. |