Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GUCY1A2 |
| Gene Name: | GUCY1A2 |
| Protein Full Name: | Guanylate cyclase soluble subunit alpha-2 |
| Mass (Da): | 81750 |
| Number AA: | 732 |
| UniProt ID: | P33402 |
| Locus ID: | 2977 |
| COSMIC ID: | GUCY1A2 |
| Gene location on chromosome: | 11q21-q22 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20178 |
| Percent of cancer specimens with mutations: | 1.31 |
| Normal role description: | Soluable guanylate cyclase 1 (GC) is a cGMP biosynthesis enzyme that is activated by nitric oxide (NO). Its role in oncogenesis in unclear. |
| Commentary on involvement of protein in cancer: | Has guanylyl cyclase on binding to the beta-1 subunit. Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits. |