Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CKS2 |
| Gene Name: | CKS2 |
| Protein Full Name: | Cyclin-dependent kinases regulatory subunit 2 |
| Alias: | CDC28 protein kinase 2; CDC28 protein kinase regulatory, 2; CKS1(Cdc28/Cdc2 kinase)-2; CKS-2; CKSHS2; Cyclin-dependent kinases regulatory, 2 |
| Mass (Da): | 9860 |
| Number AA: | 79 |
| UniProt ID: | P33552 |
| Locus ID: | 1164 |
| COSMIC ID: | CKS2 |
| Gene location on chromosome: | 9q22.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.03 |
| Normal role description: | CKS2 is a protein-serine/threonine kinase - regulatory subunit. CKS2 binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. It is implicated in a wide variety of human cancer. Expression levels positively correlate with oncogensis; low CKS2 levels induce apoptosis and high levels confer cell survival characteristics and accelerated cell cycling |