Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CNR2 |
| Gene Name: | CNR2 |
| Protein Full Name: | Cannabinoid receptor 2 |
| Alias: | CX5 |
| Mass (Da): | 39681 |
| Number AA: | 360 |
| UniProt ID: | P34972 |
| Locus ID: | 1269 |
| COSMIC ID: | CNR2 |
| Gene location on chromosome: | 1p36.11 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.34 |
| Normal role description: | CNR2 is a GPRC. A ligand of this receptor is cannabinoid delta-9-tetrahydrocannabinol. It is involved with inhibition of adenylate cyclase as well as affecting mood and cognition. It may also play a role in inflammatory response, nociceptive transmission and bone homeostasis. Other roles include signal transduction, regulation of cell fate, inhibition of vascular endothelial cell migration and downregulation of MMP2. |