Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TIE1 |
| Gene Name: | TIE1 |
| Protein Full Name: | Tyrosine-protein kinase receptor Tie-1 |
| Alias: | EC 2.7.1.112; EC 2.7.10.1; JTK14; TIE; Tie protein; Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 |
| Mass (Da): | 125090 |
| Number AA: | 1138 |
| UniProt ID: | P35590 |
| Locus ID: | 7075 |
| COSMIC ID: | TIE1 |
| Gene location on chromosome: | 1p34.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20522 |
| Percent of cancer specimens with mutations: | 1.46 |
| Normal role description: | TIE1 is an orphan receptor-tyrosine kinase that plays an essential role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signalling via TIE2. |
| Commentary on involvement of protein in cancer: | 3/359 lung cancer, and 1/11 (9%) salivary gland samlpes (mis-sense) were also mutated (Sanger COSMIC) |