Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FUS |
| Gene Name: | FUS |
| Protein Full Name: | RNA-binding protein FUS |
| Alias: | 16) in malignant liposarcoma); 75 kDa DNA-pairing protein; ALS6; FUS1; Fusion (involved in t (12; Fusion, derived from t(12;16) malignant liposarcoma; Heterogeneous nuclear ribonucleoprotein P2; Oncogene FUS; Oncogene TLS; POMp75; TLS; Translocated in liposarcoma; Translocated in liposarcoma protein |
| Mass (Da): | 53426 |
| Number AA: | 526 |
| UniProt ID: | P35637 |
| Locus ID: | 2521 |
| COSMIC ID: | FUS |
| Gene location on chromosome: | 16p11.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 21315 |
| Percent of cancer specimens with mutations: | 0.4 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | t(12;16)(q13;p11) translocation with DDIT3 found in malignant myxoid liposarcoma; t(12;16)(q13;p11) translocation with ATF-1 found in angiomatoid fibrous histiocytoma; t(7;16)(q33;p11) with CREB3L2 found in low grade fibromyxoid sarcoma; t(16;21)(p11;q22) |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | FUS is a RNA-binding protein that is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex which is involved in pre-mRNA splicing and transport of processed mRNA to the cytoplasm. Other RNA-binding proteins of its kind (part of the FET family) are known to play roles in regulation of gene expression, maintenace of genomic integrity, and mRNA and microRNA processing. A K312Q mutation has been associated in a breast cancer sample. Several translocations have been reported and implicated in angiomatoid fibrous histiocytoma, fibromyxoid sarcoma, myxoid liposarcoma, and acute myeloid leukemia. |