Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DDIT3 |
| Gene Name: | DDIT3 |
| Protein Full Name: | DNA damage-inducible transcript 3 protein |
| Alias: | C/EBP-homologous protein;C/EBP-homologous protein 10;Growth arrest and DNA damage-inducible protein GADD153 |
| Mass (Da): | 19175 |
| Number AA: | 169 |
| UniProt ID: | P35638 |
| Locus ID: | 1649 |
| COSMIC ID: | DDIT3 |
| Gene location on chromosome: | 12q13.1-q13.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20327 |
| Percent of cancer specimens with mutations: | 0.22 |
| Deregulated in translocations: | t(12;16)(q13;p11) FUS/DDIT3; t(12;22)(q13;q12) EWS/DDIT3 |
| Normal role description: | Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA. DDIT3 promotes adipogenesis, erythropoiesis apoptosis, and is involved in the endoplasmic reticulum stress response. Decreasing expression related to malignant transformation of nevi to melanomas. Mechanism of oncogensis with chimeric proteins could be mediated by loss of function of wild-type DDIT3. |