Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NUP214 |
| Gene Name: | NUP214 |
| Protein Full Name: | Nuclear pore complex protein Nup214 |
| Alias: | 214 kDa nucleoporin; CAIN; CAN; CAN protein; CAN protein, putative oncogene; D9S46E; N214; NU214; Nuclear pore complex protein Nup214; Nucleoporin 214kDa; Nucleoporin 214kDa (CAN); Nucleoporin Nup214 |
| Mass (Da): | 213620 |
| Number AA: | 2090 |
| UniProt ID: | P35658 |
| Locus ID: | 8021 |
| COSMIC ID: | NUP214 |
| Gene location on chromosome: | 9q34.1 |
| Number of cancer specimens: | 20484 |
| Percent of cancer specimens with mutations: | 1.32 |
| Deregulated in translocations: | Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Translocation t(6;9)(q21;q34.1) with SET. Fusion partners include DEK and SET. |
| Normal role description: | Nuclear pore protein. Docking site in the receptor-mediated import of substrates across the nuclear pore complex |