Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DEK |
| Gene Name: | DEK |
| Protein Full Name: | Protein DEK |
| Alias: | D6S231E; DEK oncogene; DEK oncogene (DNA binding) |
| Mass (Da): | 42674 |
| Number AA: | 375 |
| UniProt ID: | P35659 |
| Locus ID: | 7913 |
| COSMIC ID: | DEK |
| Gene location on chromosome: | 6p23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20357 |
| Percent of cancer specimens with mutations: | 0.28 |
| Deregulated in translocations: | t(6;9)(p23;q34; Acute myeloid leukemia. DEK/CAN fusion |
| Normal role description: | This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Fusion protein clearly demonstrates oncogenic potential. |