Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SOX5 |
| Gene Name: | SOX5 |
| Protein Full Name: | Transcription factor SOX-5 |
| Alias: | L-SOX5; MGC35153; SRY (sex determining region Y)-box 5 |
| Mass (Da): | 84026 |
| Number AA: | 763 |
| UniProt ID: | P35711 |
| Locus ID: | 6660 |
| COSMIC ID: | SOX5 |
| Gene location on chromosome: | 12p12.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 1.12 |
| Normal role description: | SOX5 is a transcription factor that may act as a transcriptional regulator after forming a protein complex with other proteins. It may also play a role in chondrogenesis. |
| Commentary on involvement of protein in cancer: | 1 laryngeal sample/6 total UAT samples was also mutated (mis-sense) |