Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SOX11 |
| Gene Name: | SOX11 |
| Protein Full Name: | Transcription factor SOX-11 |
| Alias: | SRY (sex determining region Y)-box 11; SRY-related HMG-box gene 11 |
| Mass (Da): | 46679 |
| Number AA: | 441 |
| UniProt ID: | P35716 |
| Locus ID: | 6664 |
| COSMIC ID: | SOX11 |
| Gene location on chromosome: | 2p25 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.66 |
| Normal role description: | May act as transcriptional activator or repressor and suggested to be important in development of many organ systems and neurogenesis. Controls morphological maturation of immature neurons and regeneration after nerve injury in adults. Overexpression associated with good prognoses in various human cancers. Candidate for T cell based immunotherapy in gliomas. |