Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MYH11 |
| Gene Name: | MYH11 |
| Protein Full Name: | Myosin-11 |
| Alias: | Myosin heavy chain, smooth muscle isoform; Myosin, heavy chain 11, smooth muscle; Myosin, heavy polypeptide 11, smooth muscle; SMHC; SMMHC |
| Mass (Da): | 227339 |
| Number AA: | 1972 |
| UniProt ID: | P35749 |
| Locus ID: | 4629 |
| COSMIC ID: | MYH11 |
| Gene location on chromosome: | 16p13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20416 |
| Percent of cancer specimens with mutations: | 2.01 |
| Deregulated in translocations: | t(16;16)(p13;q22) in acute non lymphoblastic leukaemia (ANLL) or myelodysplastic syndromes (MDS); fuses with CBFbeta. |
| Normal role description: | MYH11 is myosin belonging to the heavey chain family and it is found in smooth muscle. MYH11 functions as a major contractile protein, using ATP hydrolysis to convert chemical engery into mechanical. Myosin is integral to the actin-myosin contractile cycle found in myocytes. Translocations, t(16;16)(p13;q22), and deletions, (16)(q22), have been foudn in acute non lymphoblastic leukaemia (ANLL) or myelodysplastic syndromes (MDS) patients. |