Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CHKA |
| Gene Name: | CHKA |
| Protein Full Name: | Choline kinase alpha |
| Alias: | CHETK-alpha;Ethanolamine kinase; |
| Mass (Da): | 52249 |
| Number AA: | 457 |
| UniProt ID: | P35790 |
| Locus ID: | 1119 |
| COSMIC ID: | CHKA |
| Gene location on chromosome: | 11q13.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.32 |
| Normal role description: | CHKA is essential for phospholipid synthesis and membrane maintanence. It plays many roles in the cell including metabolism, signal tranduction, regulation and cell proiferation. It is involved in catalyzing the initial step of phosphatidylcholine and the phosphorylation of ethanolamine. Overexpression leads to increases cell growth and oncogenesis. |