Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SERPINB5 |
| Gene Name: | SERPINB5 |
| Protein Full Name: | Serpin B5 |
| Alias: | Protease inhibitor 5 |
| Mass (Da): | 42082 |
| Number AA: | 375 |
| UniProt ID: | P36952 |
| Locus ID: | 5268 |
| COSMIC ID: | SERPINB5 |
| Gene location on chromosome: | 18q21.33 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.29 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | Yes, but unknown prevalence |
| Normal role description: | SERPINB5 is structurally a serine protease inhibitor, but it does not exert such activity due to lack of the stress-to-relaxed conformational transition. Instead, it has tumour suppressor activities and blocks the growth, invasion, and invasiveness of mammary tumors and prostate cancers while promoting cellular differentiation and apoptosis. Promoter methylation may be a source of protein downregulation in normal and cancer cells. |