Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PPARG |
| Gene Name: | PPARG |
| Protein Full Name: | Peroxisome proliferator-activated receptor gamma |
| Alias: | Nuclear receptor subfamily 1 group C member 3 |
| Mass (Da): | 57620 |
| Number AA: | 505 |
| UniProt ID: | P37231 |
| Locus ID: | 5468 |
| COSMIC ID: | PPARG |
| Gene location on chromosome: | 3p25.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.49 |
| Normal role description: | PPARG is a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. It acts as a regulator of adipocyte differentiation and glucose homeostasis. Deregulation of PPARG3 levels have been found in numerous neoplasms, though its role in oncogenesis is unclear. |