Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SPAM1 |
| Gene Name: | SPAM1 |
| Protein Full Name: | Hyaluronidase PH-20 |
| Alias: | Hyaluronoglucosaminidase PH-20;Sperm adhesion molecule 1;Sperm surface protein PH-20 |
| Mass (Da): | 57848 |
| Number AA: | 509 |
| UniProt ID: | P38567 |
| Locus ID: | 6677 |
| COSMIC ID: | SPAM1 |
| Gene location on chromosome: | 7q31.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19627 |
| Percent of cancer specimens with mutations: | 0.92 |
| Normal role description: | SPAM1 is a GPI-anchored enzyme that is located on the human sperm surface and inner acrosomal membrane. It functions to degrade hyaluronic acid (HA) -- a structural proteoglycan found in extracellular matrices (ECM) and basement membranes. Dereguation or aberrant SPAM1 has been implicated in tumour progression, as increased degradation of the ECM by SPAM1 effectively weakens a critical barrier -- the basement membrane -- thereby aiding tumour metastisis. Mutations in this gene have been observed in upper aerodigestive tract (mouth and larynx) and ovarian tumors. Upregulation of this gene is associated with breast, laryngeal, colon, and skin cancer. |