Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IL6ST |
| Gene Name: | IL6ST |
| Protein Full Name: | Interleukin-6 receptor subunit beta |
| Alias: | CD130; CDw130; GP130; Gp130, oncostatin M receptor; IL6B; IL6RB; IL-6R-beta; Interleukin 6 signal transducer; Interleukin-6 receptor beta chain precursor; Membrane glycoprotein 130; Oncostatin M receptor |
| Mass (Da): | 103537 |
| Number AA: | 918 |
| UniProt ID: | P40189 |
| Locus ID: | 3572 |
| COSMIC ID: | IL6ST |
| Gene location on chromosome: | 5q11.2 |
| Cancer protein type: | OP/TSP |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20540 |
| Percent of cancer specimens with mutations: | 1.11 |
| Normal role description: | Potentiates signal transduction of IL-6 by increasing IL-6 binding affinity to IL-6 receptor. Role in oncogenesis therefore mediated through IL-6 signalling pathway which exerts different influences in different organ and cancer systems |