Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NNMT |
| Gene Name: | NNMT |
| Protein Full Name: | Nicotinamide N-methyltransferase |
| Mass (Da): | 29574 |
| Number AA: | 264 |
| UniProt ID: | P40261 |
| Locus ID: | 4837 |
| COSMIC ID: | NNMT |
| Gene location on chromosome: | 11q23.2 |
| Cancer protein type: | OP/?TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.37 |
| Normal role description: | Metabolic enzyme. Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. Implicated in the folate pathway. Upregulated in many tumour cell lines, likely related to increased metabolic demands of cancer cells. Of note, certain tumors that metastasize will downregulate this gene. |