Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SLC26A3 |
| Gene Name: | SLC26A3 |
| Protein Full Name: | Chloride anion exchanger |
| Alias: | Chloride anion exchanger; CLD; Down-regulated in adenoma; DRA; S26A3; solute carrier family 26, member 3 |
| Mass (Da): | 84505 |
| Number AA: | 764 |
| UniProt ID: | P40879 |
| Locus ID: | 1811 |
| COSMIC ID: | SLC26A3 |
| Gene location on chromosome: | 7q31.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19746 |
| Percent of cancer specimens with mutations: | 0.91 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with several point mutations, but no complex, insertion or deletion mutants. |
| Normal role description: | SLC26A3 is a chloride/bicarbonate exchanger expressed primarily in the colon. SLC26A3 is involved in the absorption of chloride in exchange for bicarbonate. Helps mediate electrolyte and fluid absorption whereby dysfunction of SLC26A3 have been associated with congenital chloride diarrhea. SLC26A3 may have a role as a tumour suppressor protein as downregulation of SLC26A3 was observed in adenocarcinomas of colon tissue. It has been speculated that loss of SLC26A3 enhances DNA synthesis due to intracellular alkalinization. |