Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BCL6 |
| Gene Name: | BCL6 |
| Protein Full Name: | B-cell lymphoma 6 protein |
| Alias: | B-cell CLL/lymphoma 6; B-cell lymphoma 6 protein homolog; Bcl5; Bcl-5; Bcl6; BCL6A; LAZ3; LAZ-3 protein; ZBTB27; Zinc finger protein 51; ZNF51 |
| Mass (Da): | 78846 |
| Number AA: | 706 |
| UniProt ID: | P41182 |
| Locus ID: | 604 |
| COSMIC ID: | BCL6 |
| Gene location on chromosome: | 3q27 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20688 |
| Percent of cancer specimens with mutations: | 0.85 |
| Deregulated in translocations: | 15-40% of Diffuse large B-cell lymphomas (DLBCL) have translocations, while 6-15% of follicular lymphomas and 50% of nodular lymphocyte predominant Hodgkin Lymphoma also exhibit tranlocations. |
| Normal role description: | BCL6 functions as a transcription factor that is necessary for germinal center formation. In B-cells, it acts as a sequence-specific repressor of START-dependent IL-4 responses. BCL6 is found to be hypermutated and translocated in diffuse large-cell lymphoma (DLCL). |
| Commentary on involvement of protein in cancer: | Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. |