Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CD200 |
| Gene Name: | CD200 |
| Protein Full Name: | OX-2 membrane glycoprotein |
| Alias: | ation molecule.">CD_antigen=CD200 |
| Mass (Da): | 31280 |
| Number AA: | 278 |
| UniProt ID: | P41217 |
| Locus ID: | 4345 |
| COSMIC ID: | CD200 |
| Gene location on chromosome: | 3q13.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19897 |
| Percent of cancer specimens with mutations: | 0.3 |
| Normal role description: | CD200 is an immunosuppressive molecule. It antagonizes inflammation, autoimmunity and adaptive immune responses. It suppreses interferon gamma induced proliferation, actiavtion and secrtion of nitrous oxide and various cytokines such as IL5, IL13 and IL6. Expression is correlated with increase metastasis and poor prognosis in cancer patients. Expression in cancer stem cells allows for evasion of host immune response. |