Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CSK |
| Gene Name: | CSK |
| Protein Full Name: | Tyrosine-protein kinase CSK |
| Alias: | CYL; EC 2.7.10.2; MPK-2 |
| Mass (Da): | 50704 |
| Number AA: | 450 |
| UniProt ID: | P41240 |
| Locus ID: | 1445 |
| COSMIC ID: | CSK |
| Gene location on chromosome: | 15q24.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19536 |
| Percent of cancer specimens with mutations: | 0.38 |
| Normal role description: | Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases. CSK downregulates tyrosine kinase activity of the SRC oncoprotein through tyrosine phosphorylation of the SRC carboxy terminus. Since cell transformation by SRC oncoproteins is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene (OMIM). |