Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ELK3 |
| Gene Name: | ELK3 |
| Protein Full Name: | ETS domain-containing protein Elk-3 |
| Alias: | ELK3; ELK3, ETS-domain protein; ERP; ETS-domain protein ELK-3; ETS-domain protein Elk-3; ETS-related protein ERP; ETS-related protein Net; ETS-related protein NET; NET; Net; SAP2; SAP-2; SRF accessory protein 2; SRF accessory protein-2; |
| Mass (Da): | 44240 |
| Number AA: | 407 |
| UniProt ID: | P4197 |
| Locus ID: | 2004 |
| COSMIC ID: | ELK3 |
| Gene location on chromosome: | 12q23 |
| Number of cancer specimens: | 20149 |
| Percent of cancer specimens with mutations: | 0.39 |
| Commentary on involvement of protein in cancer: | May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. |