Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | STAT5A |
| Gene Name: | STAT5A |
| Protein Full Name: | Signal transducer and activator of transcription 5 |
| Alias: | Mammary gland factor; MGF; MPF; STA5A; STAT5 |
| Mass (Da): | 90647 |
| Number AA: | 794 |
| UniProt ID: | P42229 |
| Locus ID: | 6776 |
| COSMIC ID: | STAT5A |
| Gene location on chromosome: | 17q11.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20524 |
| Percent of cancer specimens with mutations: | 0.46 |
| Normal role description: | Involved in signal transduction and transcriptional activation. Upon activation, STATs form homo- or heterodimers and translocate to the nucleus where they activate transcription. This process is triggered by ligands such as growth hormones, IL2, IL3, IL7 GM-CSF, erythropoietin and thrombopoietin. In myeloma and lymphoma with a TEL/JAK2 gene fusion, STAT is activated in a ligand independent manner. It was suggested that STAT has an antiapoptotic function in cells. |