Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AKR1C3 |
| Gene Name: | AKR1C3 |
| Protein Full Name: | Aldo-keto reductase family 1 member C3 |
| Alias: | 17-beta-HSD 5; 17-beta-hydroxysteroid dehydrogenase type 5; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; AK1C3; AKC1H; Aldo-keto reductase family 1, member C3; Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); Chlordecone reductase homolog; Chlordecone reductase homolog HAKRb; DD3; DD-3; DDH1; DDX; Dihydrodiol dehydrogenase 3; Dihydrodiol dehydrogenase type I; Dihydrodiol dehydrogenase X; EC 1.-.-.-; EC 1.1.-.-; EC 1.1.1.149; EC 1.1.1.188; EC 1.1.1.213; EC 1.1.1.62; EC 1.1.1.63; EC 1.1.1.64; EC 1.3.1.20; Estradiol 17-beta-dehydrogenase; HA1753; HAKRB; HAKRe; HluPGFS; HSD17B5; Hydroxysteroid (17-beta) dehydrogenase 5; KIAA0119; PGFS; Prostaglandin F synthase; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Type II 3a-hydroxysteroid dehydrogenase variant; Type IIb 3-alpha hydroxysteroid dehydrogenase |
| Mass (Da): | 36844 |
| Number AA: | 323 |
| UniProt ID: | P42330 |
| Locus ID: | 8644 |
| COSMIC ID: | AKR1C3 |
| Gene location on chromosome: | 10p15.1 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.24 |
| Normal role description: | Catalyzes the conversion of aldehydes and ketones to alchols. Metabolizes various androgen metabolites. Involves in testosterone, estrogen and progesterone metabolism.it has the capability of regulating trans-activation of various nuclear receptors. Ex; androgen receptors. Can inter convert androgens, estrogens and progestins with their cognate inactive metabolites. |