Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ARHGAP25 |
| Gene Name: | ARHGAP25 |
| Protein Full Name: | Rho GTPase-activating protein 25 |
| Alias: | KIAA0053; RHG25; Rho GTPase activating protein 25; Rho-type GTPase-activating protein 25 |
| Mass (Da): | 73417 |
| Number AA: | 645 |
| UniProt ID: | P42331 |
| Locus ID: | 9938 |
| COSMIC ID: | ARHGAP25 |
| Gene location on chromosome: | 2p13.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19763 |
| Percent of cancer specimens with mutations: | 0.8 |
| Normal role description: | ARHGAP25 is a GTPase activating protein of Rho G proteins. The overall protein contains a N-terminal pleckstrin homology domain followed by the RhoGAP domain and a C-terminal coiled-coil domain. Four alternatively spliced isoforms have been indentified. This protein has been detected by Northern blot to be expressed in lung, spleen and peripheral blood leukocytes. ARHGAP25 activates Rho monomeric G proteins which have a role in regulating actin remodeling, cell polarity, and cell migration. Dysfunction of ARHGAP25 may have a role in cancer through mediating invasiveness of tumour cells. |