Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Casp2 |
| Gene Name: | CASP2 |
| Protein Full Name: | Caspase-2 |
| Alias: | CASP-2; Caspase 2, apoptosis-related cysteine peptidase; ICH- 1L/1S; ICH1; ICH-1 protease; NEDD2 |
| Mass (Da): | 50685 |
| Number AA: | 452 |
| UniProt ID: | P42575 |
| Locus ID: | 835 |
| COSMIC ID: | CASP2 |
| Gene location on chromosome: | 7q34-q35 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.46 |
| Normal role description: | Caspase-2 is a cell death-related protease that promotes apotosis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. |
| Commentary on involvement of protein in cancer: | Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. |