Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MATK |
| Gene Name: | MATK |
| Protein Full Name: | Megakaryocyte-associated tyrosine-protein kinase |
| Alias: | EC 2.7.1.112; EC 2.7.10.2; HYL; MATK |
| Mass (Da): | 56469 |
| Number AA: | 507 |
| UniProt ID: | P42679 |
| Locus ID: | 4145 |
| COSMIC ID: | MATK |
| Gene location on chromosome: | 19p13.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20065 |
| Percent of cancer specimens with mutations: | 0.55 |
| Normal role description: | MATK is a non-receptor protein tyrosine kinase involved in signalling in hematopoietic cells. MATK has been found to inhibit Src family kinases which inhibits T-cell proliferation. Mis-sense mutations have been identified in colorectal, ovarian, stomach and breast cancers but their functional effect is not well characterized. Due to MATK's antiproliferative activities, it may function as a tumour suppressor protein. |
| Commentary on involvement of protein in cancer: | Less than 3% mutations in large intestine, and skin cancers. |