Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FRK |
| Gene Name: | FRK |
| Protein Full Name: | Tyrosine-protein kinase FRK |
| Alias: | EC 2.7.1.112; EC 2.7.10.2; Nuclear tyrosine protein kinase RAK |
| Mass (Da): | 58254 |
| Number AA: | 505 |
| UniProt ID: | P42685 |
| Locus ID: | 2444 |
| COSMIC ID: | FRK |
| Gene location on chromosome: | 6q22.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20203 |
| Percent of cancer specimens with mutations: | 0.55 |
| Normal role description: | FRK is a protein-tyrosine kinase. It is involved in positive regulation of PTEN by increasing its stability and preventing degradation and negative regulation of cell proliferation. It may also have functions during G1 and S phase in the nucleus to suppress growth. |