Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DCC |
| Gene Name: | DCC |
| Protein Full Name: | Netrin receptor DCC |
| Alias: | colorectal cancer suppressor; deleted in colorectal carcinoma; IGDCC1; immunoglobulin superfamily, DCC subclass, member 1; netrin receptor DCC; tumor suppressor protein DCC |
| Mass (Da): | 158457 |
| Number AA: | 1447 |
| UniProt ID: | P43146 |
| Locus ID: | 1630 |
| COSMIC ID: | DCC |
| Gene location on chromosome: | 18q21.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19952 |
| Percent of cancer specimens with mutations: | 2.94 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with some point mutations , but no complex mutations, insertions or deletions. |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | DCC is part of the immunoglobulin superfamily as a netrin receptor required for axon attraction of neuronal growth cones during development of the nervous system. It can also act to induce apoptosis via a netrin-independent mechanism and thus implicated as a tumour suppressor gene. Mutations and deletions of this gene has been associated particularly with colorectal cancers and esophageal cancers. |