Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NR4A3 |
| Gene Name: | NR4A3 |
| Protein Full Name: | Nuclear receptor subfamily 4 group A member 3 |
| Alias: | CHN; CSMF; MINOR; Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; NOR1; Nuclear receptor subfamily 4, group A, member 3 (NOR1); Orphan nuclear receptor TEC |
| Mass (Da): | 68230 |
| Number AA: | 626 |
| UniProt ID: | P43354 |
| Locus ID: | 8013 |
| COSMIC ID: | NR4A3 |
| Gene location on chromosome: | 9q22 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.78 |
| Deregulated in translocations: | Extraskeletal myxoid chondrosarcoma. Fusion partners include EWSR1, TAF2N and TCF12 |
| Normal role description: | Binds to the B1A response-element. |