Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Rap1GAP |
| Gene Name: | RAP1GAP |
| Protein Full Name: | Rap1 GTPase-activating protein 1 |
| Alias: | KIAA0474; RAP1 GTPase activating protein; RAP1GA1; RAP1GAP1; RAP1GAPII; RGP2; RPGP1 |
| Mass (Da): | 73361 |
| Number AA: | 663 |
| UniProt ID: | P47736 |
| Locus ID: | 5909 |
| COSMIC ID: | RAP1GAP |
| Gene location on chromosome: | 1p36.1-p35; 1p36.12 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19735 |
| Percent of cancer specimens with mutations: | 0.5 |
| Normal role description: | RAP1GAP is a GTPase activating protein for monomeric Ras-related RAP1 G-proteins. RAP1 is involved in signalling to activate cell growth, proliferation and differentiation in response to mitogenic signals. RAP1GAP activates the GTPase activity of RAP1 to convert it from an activated GTP bound state to an inactive GDP bound state. Thus RAP1GAP negatively regulates RAP1 activity. Loss of RAP1GAP activity has been implicated in papillary thyroid cancer, pancreatic cancer, prostate cancer and melanoma tumours. Decreased RAP1GAP activity would promote RAP1-mediated cell proliferation and growth which would promote tumour growth. RAP1GAP can be classified as a tumour suppressor protein. |