Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ID4 |
| Gene Name: | ID4 |
| Protein Full Name: | DNA-binding protein inhibitor ID-4 |
| Alias: | Class B basic helix-loop-helix protein 27;Inhibitor of DNA binding 4 |
| Mass (Da): | 16622 |
| Number AA: | 161 |
| UniProt ID: | P47928 |
| Locus ID: | 3400 |
| COSMIC ID: | ID4 |
| Gene location on chromosome: | 6p22.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.08 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | Yes in non-hodgkin lymphomas, breast cancer, gastric cancer, colorectal cancer |
| Normal role description: | ID4 is a HLH protein that has transcriptional corepressor functions. This particular HLH protein is unable to bind to DNA due to lack of a basic DNA-binding domain, but it is able to form heterodimers with other HLH proteins to inhibit DNA binding. ID4 was silenced by methylation in the majority of human leukemias, and transfection of mouse ID4 into a mouse lymphoid tumour inhibited cell growth in vitro. It has been suggested that ID4 enhances Rb1-mediated inhibition of proliferation of differentiating neurons. It may therefore have tumour suppressor functions. Other ID proteins play important roles in early embryonic processes, growth, differentiation, senescence and apoptosis, and also angiogenesis. |