Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CD151 |
| Gene Name: | CD151 |
| Protein Full Name: | CD151 antigen |
| Alias: | GP27;Membrane glycoprotein SFA-1;Platelet-endothelial tetraspan antigen 3;Tetraspanin-24 |
| Mass (Da): | 28295 |
| Number AA: | 253 |
| UniProt ID: | P48509 |
| Locus ID: | 977 |
| COSMIC ID: | CD151 |
| Gene location on chromosome: | 11p15.5 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.16 |
| Transduced into viral genome: | HTLV-1 |
| Normal role description: | Involved in integrin signalling pathway and cell interaction with surrounding matrix. Essential for the formation of the normal renal basement membrane. Also involved in angiogensis. High levels correlate with poor prognosis for a variety of cancer and silencing CD151 appears to slow tumour progression. This indicated the possible role of CD151 as a tumour promoter |