Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NRIP1 |
| Gene Name: | NRIP1 |
| Protein Full Name: | Nuclear receptor-interacting protein 1 |
| Alias: | NRIP1; Nuclear factor RIP140; Nuclear receptor interacting protein 1; Receptor interacting protein 140 |
| Mass (Da): | 126942 |
| Number AA: | 1158 |
| UniProt ID: | P48552 |
| Locus ID: | 8204 |
| COSMIC ID: | NRIP1 |
| Gene location on chromosome: | 21q21.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19719 |
| Percent of cancer specimens with mutations: | 0.94 |
| Normal role description: | NRIP1 is a nuclear protein that has been found to interact with the hormone-dependent activation domain AF2 of nuclear receptors and to modulate their transcriptional repression by recruiting histone deacetylases and CtBP. It also modulates transcriptional activation by steroid receptors such as the estrogen receptor. In vitro, NRIP1 has been shown to regulate retinoic acid-mediated differentiation and growth suppression of human embryonal carcinoma cells, as well as the proliferation of breast cancer cells, and the fact that it functions to inhibit the activity of several nuclear receptors suggests that it may play a role in hormone-dependent cancers, but it so far remains only a theory. |
| Commentary on involvement of protein in cancer: | 1/1 laryngeal samples was mutated (mis-sense) |