Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SERPINB4 |
| Gene Name: | SERPINB4 |
| Protein Full Name: | Serpin B4 |
| Alias: | LEUPIN; PI11; Protease inhibitor (leucine-serpin); SCCA1; SCCA2; SCCA-2; Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4; Serpin peptidase inhibitor, clade B (ovalbumin), member 4; SPB4; Squamous cell carcinoma antigen 1; Squamous cell carcinoma antigen 2 |
| Mass (Da): | 44854 |
| Number AA: | 390 |
| UniProt ID: | P48594 |
| Locus ID: | 6318 |
| COSMIC ID: | SERPINB4 |
| Gene location on chromosome: | 18q21.33 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.74 |
| Normal role description: | Serpin B4 may act as a protease inhibitor to modulate the host immune response against tumour cells |
| Commentary on involvement of protein in cancer: | 1 laryngeal sample/out of 4 total UAT samples, was also mutated (silent) |