Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CSNK1A1 |
| Gene Name: | CSNK1A1 |
| Protein Full Name: | Casein kinase I isoform alpha |
| Alias: | Casein kinase 1, alpha 1; Casein kinase I, alpha isoform; CK1; CK1-alpha; CKI-alpha; EC 2.7.11.1; KC1A; Kinase CK1-alpha |
| Mass (Da): | 38915 |
| Number AA: | 337 |
| UniProt ID: | P48729 |
| Locus ID: | 1452 |
| COSMIC ID: | CSNK1A1 |
| Gene location on chromosome: | 5q32 |
| Cancer protein type: | MIXED |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20341 |
| Percent of cancer specimens with mutations: | 0.28 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | CSNK1A1 is a cytoplasmic kinase that may phosphorylate many proteins and participate in many signalling pathways, such as a negative regulator of the Wnt pathway. While it may function as a tumour suppressor by inhibiting the Wnt pathway for example, it may also function as a oncoprotein by stimulating cytokine production and lymphocyte proliferation, and also prevent apoptosis. It may also play a role in chromosomal segregation during mitosis. |